The resistance determinant profiles of these 16 E. The blaCTX-M and/or blaAmpC β-lactamase genes plus porin loss were detected in 47 non-carbapenemase-producing isolates (16 E.

Among the 92 isolates in this study, only nine (9.8 %) isolates were detected with carbapenemase genes. PCRs were used to detect carbapenemase genes (blaNDM, blaKPC, blaIMP, blaVIM and blaOXA-48), blaCTX-M ESBL genes and blaAmpC genes. pneumoniae isolates recovered from the Hong Kong West Cluster hospitals from 2010 to 2012. Firstly, we investigated the carbapenem resistance mechanism of carbapenem-resistant E. Further investigation is needed to elucidate the situation. However, the previous findings fail to explicate the carbapenem resistance mechanisms of the remaining non-carbapenemase producing isolates. Notably, a novel IncX3 plasmid was found to be involved in the dissemination of blaNDM-1 gene. The findings of the previous study showed that 26.1% of the Enterobacteriaceae isolates were confirmed to produce carbapenemase. In 2012, our group has documented the emergence of carbapenem-resistant clinical isolates in Hong Kong. pneumoniae are increasingly reported in Hong Kong. pneumoniae limits treatment options of the infection, poses severe challenges to clinical professionals and threatens our health. The wide spread of carbapenem-resistant E. Besides, successful epidemic plasmids were reported to disseminate carbapenemase genes in Enterobacteriaceae. Molecular epidemiology studies have shown that there is a global dissemination of epidemic clones of carbapenem-resistant E. pneumoniae has become a serious public health problem over the last decade. Increasing carbapenem resistance among clinical isolates of E.

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